A two-phase two-layer model for transdermal drug delivery and percutaneous absorption
نویسندگان
چکیده
منابع مشابه
A two-phase two-layer model for transdermal drug delivery and percutaneous absorption.
One of the promising frontiers of bioengineering is the controlled release of a therapeutic drug from a vehicle across the skin (transdermal drug delivery). In order to study the complete process, a two-phase mathematical model describing the dynamics of a substance between two coupled media of different properties and dimensions is presented. A system of partial differential equations describe...
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BACKGROUND When a drug is applied on the skin surface, the concentration of the drug accumulated in the skin and the amount of the drug eliminated into the blood vessel depend on the value of a parameter, r. The values of r depend on the amount of diffusion and the normalized skin-capillary clearance. It is defined as the ratio of the steady-state drug concentration at the skin-capillary bounda...
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One of the most promising frontiers of bioengineering is the controlled release of a therapeutic drug from a vehicle across the skin (transdermal drug delivery). In order to study the complete process, a multiphase mathematical model describing the dynamics of a substance between two porous coupled media of different properties and extents is presented. A system of partial differential equation...
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ژورنال
عنوان ژورنال: Mathematical Biosciences
سال: 2014
ISSN: 0025-5564
DOI: 10.1016/j.mbs.2014.05.001